NDC: 50090-4592-0 40 CAPSULE in a BOTTLE
NDC: 50090-4592-1 20 CAPSULE in a BOTTLE
NDC: 50090-4592-2 10 CAPSULE in a BOTTLE
NDC: 50090-4592-3 12 CAPSULE in a BOTTLE
NDC: 50090-4592-4 4 CAPSULE in a BOTTLE
NDC: 50090-4592-5 5 CAPSULE in a BOTTLE
NDC: 50090-4592-6 14 CAPSULE in a BOTTLE
NDC: 50090-4592-7 11 CAPSULE in a BOTTLE
NDC: 50090-4592-8 500 CAPSULE in a BOTTLE
Hyperpigmentation of the thyroid has been produced by members of the tetracycline class in the following species: in rats by oxytetracycline, doxycycline, tetracycline PO4 , and methacycline; in minipigs by doxycycline, minocycline, tetracycline PO4 , and methacycline; in dogs by doxycycline and minocycline; in monkeys by minocycline.
Minocycline, tetracycline PO4 , methacycline, doxycycline, tetracycline base, oxytetracycline HCl, and tetracycline HCl were goitrogenic in rats fed a low iodine diet. This goitrogenic effect was accompanied by high radioactive iodine uptake. Administration of minocycline also produced a large goiter with high radioiodine uptake in rats fed a relatively high iodine diet.
Treatment of various animal species with this class of drugs has also resulted in the induction of thyroid hyperplasia in the following: in rats and dogs (minocycline); in chickens (chlortetracycline); and in rats and mice (oxytetracycline). Adrenal gland hyperplasia has been observed in goats and rats treated with oxytetracycline.
- Friedman JM and Polifka JE. Teratogenic Effects of Drugs. A Resource for Clinicians (TERIS). Baltimore, MD: The Johns Hopkins University Press, 2000: 149–195.
- Cziezel AE and Rockenbauer M. Teratogenic study of doxycycline. Obstet Gynecol 1997; 89: 524–528.
- Horne HW Jr and Kundsin RB. The role of mycoplasma among 81 consecutive pregnancies: a prospective study. Int J Fertil 1980; 25: 315–317.
- Hale T. Medications and Mothers Milk. 9th edition. Amarillo, TX: Pharmasoft Publishing, 2000: 225–226.
This product’s label may have been updated. For current full prescribing information, please visit www.amneal.com
Amneal Pharmaceuticals Pvt. Ltd.
Ahmedabad 382220, INDIA
Amneal Pharmaceuticals LLC Bridgewater, NJ 08807
Store at 20° to 25°C (68° to 77°F); excursions permitted between 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature]. Dispense in tight, light-resistant containers as defined in the USP.
|DOXYCYCLINE HYCLATE doxycycline capsule|
|Labeler — A-S Medication Solutions (830016429)|
|A-S Medication Solutions||830016429||RELABEL (50090-4592), REPACK (50090-4592)|
Revised: 11/2019 A-S Medication Solutions
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